Regina Nathan's career in opera, concert and recital has taken her from her native Ireland across Europe, and as far as Kuala Lumpur and New York's Carnegie Hall.

She has appeared in opera at Madrid's Teatro Réal, Brussels' La Monnaie, the Hamburg Staatsoper, Opéra de Genève, Luzern Stadttheater, Israeli Opera, Scottish Opera, Opera de Nice, Opéra de Nantes, Glyndebourne Touring Opera, Opera Zuid, Stadttheater Giessen, as well as Opera Ireland.
She has sung major lyric soprano roles throughout her career. Her repertoire ranges from the title role in Cavalli's La Calisto to the world-premiere of Mark Anthony Turnage's The Country of the Blind for the Aldeburgh Festival/English National Opera. Regina has appeared as Carlisle Floyd's Susannah, Moore’s Baby Doe, Gluck's Euridice, Verdi's Violetta, Bizet's Léïla, Offenbach's Antonia and Amelia in Verdi’s Un Ballo in Maschera. Her portrayal of the role of Puccini's Cio Cio San in Madama Butterfly for Opera Ireland and at the Stadttheater Giessen was hailed with critical acclaim as was her role of Cleopatra in Handel's Julius Caesar and Norma in Bellin’s Norma.

Regina has worked with conductors such as Antonio Pappano, Edo De Waart, Kent Nagano, and Frans Bruggen. Mahler's Eighth Symphony has taken her to Amsterdam's Concertgebouw, London's Royal Albert Hall, and the opening concert of Manchester's Bridgewater Hall; Mahler's Fourth Symphony and Mozart's Exsultate Jubilate to Brussels and Israel, and Rachmaninov's The Bells to London's Royal Festival Hall.

A devoted recitalist, Regina Nathan's talents also embrace everything from classic Lieder to traditional Irish song. She has enraptured audiences throughout Ireland, London's Wigmore Hall, the Purcell Room, the Théâtre du Châtelet in Paris and famously with Placido Domingo in a sold out audience at Dublin's Point Theatre.

Her recordings include Britten, Complete Folk Song Arrangements (Hyperion), Mahler’s Symphony No.8 (BMG), Donizetti’s Maria de Rudenz (Opera Rara) and of course Faith of our Fathers, alongside Frank Patterson. She has also recorded two solo CD's, "With Love" (Lunar Records)and the CD "Ave Maria" with the Prague Philharmonic Orchestra.